Immunosuppression by co-trimoxazole.

Co-trimoxazole induced aseptic meningitis.

A 15 year old boy presented with two episodes of aseptic meningitis-like reactions after ingestion of co-trimoxazole. The diagnosis of co-trimoxazole induced aseptic meningitis was made. This syndrome should be considered in the differential diagnosis of aseptic meningitis.

Pseudomembranous colitis and co-trimoxazole.

An 80-year-old woman was admitted to hospital with a fractured neck of the femur, which was managed by internal fixation. Antibiotic cover was not provided for the operation. On the sixth day after operation she developed a fever, which was clinically attributed to a urinary infection, although no organism was subsequently cultured. Treatment was started with cotrimoxazole (Septrin), two tablet...

Thrombophlebitis migrans following co-trimoxazole therapy.

We report an unusual and severe vasculitic disorder following co-trimoxazole, given orally for a urinary tract infection. The vasculitis was manifest solely as thrombophlebitis migrans and involving only veins without evidence of polyarteritis nodosa, or underlying malignancy.

Co-trimoxazole red cell aplasia in leukaemia.

A 4 year old boy with acute lymphoblastic leukaemia developed a pure red cell aplasia 13 months after entering remission and while on maintenance chemotherapy. Co-trimoxazole was also being administered for prophylaxis against Pneumocystis carinii infection. When co-trimoxazole was stopped the red cell aplasia resolved.

Acute tubular necrosis following co-trimoxazole therapy.